LOX-1 The Multifunctional Receptor Underlying Cardiovascular Dysfunction

The Lox-1 Scavenger Receptor and Atherosclerotic Plaque Rupture

Atherosclerosis is a chronic systemic inflammatory disease; the end-stage of which is plaque rupture. This depends on plaque composition and vulnerability rather than the severity of stenosis [1]. Vulnerable plaques are associated with an intense inflammatory response and a thin fibrous cap [2]. Remodeling and degradation of the extracellular matrix (ECM) and fibrous cap are maintained by the p...

LOX-1 protein, A Biomarker in the Prognosis of Atherosclerosis

LOX-1 is a class E scavenger receptor that mediates the uptake of oxLDL by vascular cells. LOX-1 is involved in endothelial dysfunctions, monocyte adhesion, the proliferation, migration, and apoptosis of smooth muscle cells, foam cell formation, platelet activation, as well as plaque instability; all of these events are critical in the pathogenesis of atherosclerosis. These LOX-1-dependent bio...

J.Biol.Macromol,, 7(2) 11-22 (2007) Review Oxidized low-density lipoprotein receptor, LOX-1, on the endothelial cell – The receptor structure and functions of LOX-1 in atherogenesis

LOX-1 boosts immunity

Lectin-like oxidized low-density lipoprotein (LDL) receptor-1 (LOX-1) is a class E scavenger receptor that is encoded by the OLR1 gene on human chromosome 12. LOX-1 is expressed as a type II transmembrane protein containing four domains: an extracellular C-terminal lectin domain, a connecting neck domain, a single transcellular domain and a short N-terminal cytoplasmic tail. A disulfide bond be...

Histamine increases the expression of LOX-1 via H2 receptor in human monocytic THP-1 cells.

Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is a member of the scavenger receptor family, and is known to be expressed in monocytes/macrophages. We investigated the effect of histamine on the expression of LOX-1 in cells of the human monocytic leukemia cell line THP-1. Histamine as well as forskolin and dibutyryl cyclic AMP (Bt2-cAMP) stimulated the THP-1 monocytes to expres...